DNA Gyrase-IN-9
DNA Gyrase-IN-9 (compound 4j) is an antibacterial agent that targets DNA gyrase. The MIC to inhibit Gram bacteria is 0.5-2 μg/mL, and the MBC to kill Gram bacteria is 2-8 μg/mL. DNA Gyrase-IN-9 inhibits DNA gyrase in Staphylococcus aureus with IC50=6.29 μg/mL[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dna-gyrase-in-9.html
Solubility
10 mM in DMSO
Smiles
N#CC(C1C2=CC=C(C3=CC=CC=C3)C=C2)=C(O)OC4=C1C(C)=NN4C5=CC=C(Cl)C=C5
Molecular Formula
C26H18ClN3O2
Molecular Weight
439.89
References & Citations
[1]Almaghrabi M, et al. Introducing of novel class of pyrano [2, 3-c] pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation[J]. Journal of Biomolecular Structure and Dynamics, 2023: 1-18.. . .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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