SIRT5 inhibitor 8
SIRT5 inhibitor 8 (compound 10) is a competitive inhibitor (IC50: 5.38 μM) of sirtuin SIRT5 with anticancer potential[1].
Product Specifications
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt5-inhibitor-8.html
Solubility
10 mM in DMSO
Smiles
ClC(C=CC=C1)=C1NC2=NC(NC3=CC=CC=C3)=NC(NCCCNC(NCCC(O)=O)=S)=N2
Molecular Formula
C22H25ClN8O2S
Molecular Weight
501.00
References & Citations
[1]Wang L, et al. Design, synthesis and biological evaluation of 2,4,6- trisubstituted triazine derivatives as new nonpeptide small-molecule SIRT5 inhibitors. Bioorg Med Chem. 2023 Oct 1;93:117455.. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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