WK499
BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. BCL6-IN-10 interrupts the binding of BCL6 to SMRT protein. BCL6-IN-10 induces cell apoptosis, cell cycle arrest and DNA damage. BCL6-IN-10 inhibits AML cell proliferation (IC50s: 0.91, 1.63, 1.026, 7.42, 0.87, 0.85μM for OCl-AML3, THP1, MOLM13, HL60, KG1, NB4 cell respectively) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wk499.html
Solubility
10 mM in DMSO
Smiles
O=C(O1)C=CC2=C1C=CC(NC3=CC(N4CCCC(NC(CBr)=O)C4)=NC5=NC=NN53)=C2
Molecular Formula
C21H20BrN7O3
Molecular Weight
498.33
References & Citations
[1]Zhang L, et al. A small molecule BCL6 inhibitor as chemosensitizers in acute myeloid leukemia. Biomed Pharmacother. 2023 Oct;166:115358.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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