EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is a EGFR, BRAFV600E and EGFRT790M inhibitor with IC50 value of 57 nM, 68 nM and 9.70 nM. EGFR/BRAFV600E-IN-3 is an apoptotic inducer and also displays promising antioxidant activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/egfr-brafv600e-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=C(OC)C=C2)C(N3N=NC(C(C4=CC=CC=C4)=O)=C3C5=CC=CC=C5)=C1
Molecular Formula
C25H18N4O3
Molecular Weight
422.44
References & Citations
[1]El-Sheref EM, et al. Synthesis, Antioxidant and Antiproliferative Actions of 4- (1,2,3-Triazol-1-yl) quinolin-2 (1H) -ones as Multi-Target Inhibitors. Int J Mol Sci. 2023 Aug 27;24 (17) :13300.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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