EGFR/BRAFV600E-IN-2
Product Specifications
UNSPSC Description
E07 aptamer is an aptamer that targets human epidermal growth factor receptor (hEGFR). E07 aptamer can compete with EGF for binding, binds to a novel epitope on EGFR. E07 aptamer binds to cells expressing EGFR, blocks receptor autophosphorylation, and prevents proliferation of tumor cells in three-dimensional matrices. E07 aptamer can be used for tomor disease research[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-brafv600e-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=C(C)C=C2)C(N3N=NC(C(C4=CC=CC=C4)=O)=C3C5=CC=CC=C5)=C1
Molecular Weight
406.44
References & Citations
[1]Li N, et al. Inhibition of cell proliferation by an anti-EGFR aptamer. PLoS One. 2011;6(6):e20299. doi: 10.1371/journal.pone.0020299. Epub 2011 Jun 8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149517/EGFR-BRAFV600E-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149517/
Clinical Information
No Development Reported
Curated Selection
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