EP12
Product Specifications
UNSPSC Description
EP12 is a c-Myc inhibitor. EP12 is a c-Myc G4 stabilizer. EP12 induces apoptosis and DNA damage in multiple myeloma cells. EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway. EP12 inhibits multiple myeloma growth[1].
Target Antigen
Apoptosis; c-Myc
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ep12.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C2=CC(C3=NC4=C(C=CC=C4)N3CCOC5=CC(C)=CC(C)=C5)=NO2)C=C1
Molecular Weight
427.47
References & Citations
[1]Yao R, et al. Novel c-Myc G4 stabilizer EP12 promotes myeloma cytotoxicity by disturbing NF-κB signaling. Exp Cell Res. 2023 Oct 1;431(1):113759.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149513/EP12-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149513/
Clinical Information
No Development Reported
CAS Number
2882916-73-4
Curated Selection
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