EP12

EP12 is a c-Myc inhibitor. EP12 is a c-Myc G4 stabilizer. EP12 induces apoptosis and DNA damage in multiple myeloma cells. EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway. EP12 inhibits multiple myeloma growth[1].

Product Specifications

CAS Number

[2882916-73-4]

UNSPSC

12352005

Target

Apoptosis; c-Myc

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ep12.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(C2=CC(C3=NC4=C(C=CC=C4)N3CCOC5=CC(C)=CC(C)=C5)=NO2)C=C1

Molecular Formula

C26H22FN3O2

Molecular Weight

427.47

References & Citations

[1]Yao R, et al. Novel c-Myc G4 stabilizer EP12 promotes myeloma cytotoxicity by disturbing NF-κB signaling. Exp Cell Res. 2023 Oct 1;431 (1) :113759.