α-Synuclein inhibitor 9

α-Synuclein inhibitor 9 (Compound 20C) is an α-Synuclein inhibitor. α-Synuclein inhibitor 9 binds to cavities in mature α-synuclein fibrils and reduces the β-sheet structure. α-Synuclein inhibitor 9 inhibits A53T α-Syn aggregation. α-Synuclein inhibitor 9 has neuroprotective effect, improves brain functional connection and relieves motor dysfunction.α-Synuclein inhibitor 9 can be used for Parkinson’s disease (PD) research.[1].

Product Specifications

CAS Number

[1510825-03-2]

UNSPSC

12352005

Target

α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-synuclein-inhibitor-9.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(CC2=CC=C(C(CC3=CC=C(C(CC4=CC=C(C=C4)O)=C3)O)=C2)O)C=C1

Molecular Formula

C27H24O4

Molecular Weight

412.48

References & Citations

[1]Peng Y, et al. A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson's disease. Cell Death Dis. 2023 Sep 6;14 (9) :594.