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CP-07

CP-07 is a potent and selective PROTACCDK9 degrader (DC50: 43 nM) . CP-07 inhibits 22RV1 cell proliferation (IC50: 62 nM) and colony formation by down-regulating Mcl-1 and c-Myc. CP-07 inhibits 22RV1 xenograft tumor growth. CP-07 can be used for research of prostate cancer[1].

Product Specifications

UNSPSC

12352005

Target

CDK; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cp-07.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(O)=C(C(C=C(C2=CC=C(N3CCN(CC4CCN(C5=CC=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=C5)CC4)CC3)C=C2)O8)=O)C8=C1C9=CCN(C)CC9

Molecular Formula

C45H48N6O8

Molecular Weight

800.90

References & Citations

[1]Wu T, et al. Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy. Eur J Med Chem. 2023 Nov 15;260:115774.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK9

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