CP-07
CP-07 is a potent and selective PROTACCDK9 degrader (DC50: 43 nM) . CP-07 inhibits 22RV1 cell proliferation (IC50: 62 nM) and colony formation by down-regulating Mcl-1 and c-Myc. CP-07 inhibits 22RV1 xenograft tumor growth. CP-07 can be used for research of prostate cancer[1].
Product Specifications
UNSPSC
12352005
Target
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cp-07.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(O)=C(C(C=C(C2=CC=C(N3CCN(CC4CCN(C5=CC=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=C5)CC4)CC3)C=C2)O8)=O)C8=C1C9=CCN(C)CC9
Molecular Formula
C45H48N6O8
Molecular Weight
800.90
References & Citations
[1]Wu T, et al. Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy. Eur J Med Chem. 2023 Nov 15;260:115774.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
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