IHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective, orally active PI3Kγ/δ dual inhibitor with IC50s of 7.1 nM and 0.57 nM for PI3Kγ and PI3Kδ, respectively. IHMT-PI3K-455 suppresses the AKT phosphorylation. IHMT-PI3K-455 inhibits tumor growth by recruiting and activating more CD8+ killing T cells.IHMT-PI3K-455 is used in cancer research[1].
Product Specifications
CAS Number
3047746-40-4
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ihmt-pi3k-455.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)N=CC(C2=NC3=CC(NC4=CC=CC(CNC(C5=C(F)C=CC=C5F)=O)=N4)=NN3C=C2)=C1
Molecular Formula
C26H21F2N7O3
Molecular Weight
517.49
References & Citations
[1]Liang X, et al. Discovery of Pyrazolo[1,5-a]pyrimidine derivative as a potent and selective PI3Kγ/δ dual inhibitor. Eur J Med Chem. 2023 Nov 15;260:115768.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Frequently Asked Questions
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