JH-131e-153
JH-131e-153, a diacylglycerol (DAG) -lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases[1].
Product Specifications
CAS Number
742104-91-2
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jh-131e-153.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C)C(OC[C@@](C/C1=C/CC(CC(C)C)CC(C)C)(CO)OC1=O)=O
Molecular Formula
C22H38O5
Molecular Weight
382.53
References & Citations
[1]Das J, et al. Activation of Munc13-1 by Diacylglycerol (DAG) -Lactones. Biochemistry. 2023 Aug 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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