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FGFR1 inhibitor-9

FGFR1 inhibitor-9 (Compound 7) is an FGFR1 inhibitor (IC50s: 0.85 nM) . FGFR1 inhibitor-9 binds to the ATP-binding pocket of FGFR1. FGFR1 inhibitor-9 has anticancer activity[1].

Product Specifications

UNSPSC

12352005

Target

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fgfr1-inhibitor-9.html

Solubility

10 mM in DMSO

Smiles

O=C1C(Cl)=C(NC2=CC=C(C(/C=C/C3=CC=C(OC)C(OC)=C3)=O)C=C2)C(C4=C1C=CC=C4)=O

Molecular Formula

C27H20ClNO5

Molecular Weight

473.90

References & Citations

[1]Ronnakorn Leechaisit, et al. Discovery of Novel Naphthoquinonehalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling. ACS Omega 2023.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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