FGFR1 inhibitor-8
FGFR1 inhibitor-8 (Compound 9) is a FGFR1 inhibitor (IC50s: 0.5 nM) . FGFR1 inhibitor-8 binds to the ATP-binding pocket of FGFR1. FGFR1 inhibitor-8 has anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr1-inhibitor-8.html
Solubility
10 mM in DMSO
Smiles
O=C1C(Cl)=C(NC2=CC=C(C(/C=C/C3=CC=C(OC)C(O)=C3)=O)C=C2)C(C4=C1C=CC=C4)=O
Molecular Formula
C26H18ClNO5
Molecular Weight
459.88
References & Citations
[1]Ronnakorn Leechaisit, et al. Discovery of Novel Naphthoquinonehalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling. ACS Omega 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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