FGFR1 inhibitor 7
FGFR1 inhibitor 7 (compound 5) is an inhibitor of FGFR1 Tyrosine Kinase with IC50 value of 0.33 nM. FGFR1 inhibitor 7 shows broad-spectrum cytotoxicity agasinst human cancer cell lines, and inhibits MOLT3 cells with IC50 of 2.1 μM[1].
Product Specifications
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr1-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
O=C1C(Cl)=C(NC2=CC=CC(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)C(C4=C1C=CC=C4)=O
Molecular Formula
C25H16ClNO4
Molecular Weight
429.85
References & Citations
[1]Leechaisit R, et al. Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling[J]. ACS Omega, 2023. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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