FGFR1 inhibitor 7
FGFR1 inhibitor 7 (compound 5) is an inhibitor of FGFR1 Tyrosine Kinase with IC50 value of 0.33 nM. FGFR1 inhibitor 7 shows broad-spectrum cytotoxicity agasinst human cancer cell lines, and inhibits MOLT3 cells with IC50 of 2.1 μM[1].
Product Specifications
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr1-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
O=C1C(Cl)=C(NC2=CC=CC(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)C(C4=C1C=CC=C4)=O
Molecular Formula
C25H16ClNO4
Molecular Weight
429.85
References & Citations
[1]Leechaisit R, et al. Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling[J]. ACS Omega, 2023. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC423178 20 µg
IRAK1BP1 (NM_001010844) Human Over-expression Lysate
Sign In for Pricing
View Details