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JNK2-IN-1

JNK2-IN-1 (Compound J27) is a JNK2 inhibitor (Kds: 79.2 μM) . JNK2-IN-1 has anti-inflammatory activity. JNK2-IN-1 decreases the release of TNF-α and IL-6 through inhibiting the activation of NF-κB/MAPK pathway. JNK2-IN-1 alleviates the symptoms of LPS-induced acute lung injury (ALI) and sepsis[1].

Product Specifications

CAS Number

2998941-15-2

UNSPSC

12352005

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jnk2-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(C=C1)N2C(C=C(C(C(NC3=CC=C(OC4=C5C(C=C(C(OC)=C5)OC)=NC=C4)C=C3)=O)=N2)C)=O

Molecular Formula

C30H26N4O5

Molecular Weight

522.55

References & Citations

[1]Liao J, et al. Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-B/MAPK Pathway. J Med Chem. 2023 Aug 29.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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