AChE-IN-39

AChE-IN-39 (Compound 7c) is an AChE inhibitor (IC50: 0.058 μM) . AChE-IN-39 has DPPH scavenging activity. AChE-IN-39 improves the cognitive impairment in AlCl3-induced amnesia animal model. AChE-IN-39 can be used for research of Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-in-39.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(C=CC=C2)O1)/C=C/NC3=CC(C(C)=O)=CC=C3

Molecular Formula

C19H15NO3

Molecular Weight

305.33

References & Citations

[1]Somaia S. Abd El-Karim, et al. Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation. European Journal of Medicinal Chemistry. 2013, 115766.