CDK2/Bcl2-IN-1
Product Specifications
UNSPSC Description
CDK2/Bcl2-IN-1 (compound 1), a saponin and a CDK-2 inhibitor (IC50=117.6 nM) with promising cytotoxicity against cancer cells. CDK2/Bcl2-IN-1 also inhibits Bcl-2, and induces apoptosis in A549 lung cancer cells[1].
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-bcl2-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC[C@@]2(C(O[C@@H]3[C@@H](OS(=O)(O)=O)[C@H](O)[C@H](O)CO3)=O)CC[C@@]4(C)[C@]5(C)CCC6C(C)(C)[C@@H](O)CC[C@]6(C)C5CCC4C2[C@H]1C
Molecular Weight
668.88
References & Citations
[1]Eltamany EE, et al. A New Saponin (Zygo-albuside D) from Zygophyllum album Roots Triggers Apoptosis in Non-Small Cell Lung Carcinoma (A549 Cells) through CDK-2 Inhibition. ACS Omega. 2023 Aug 8;8(33):30630-30639.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149436/CDK2-Bcl2-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149436/
Clinical Information
No Development Reported
Curated Selection
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