NDNA3
Product Specifications
UNSPSC Description
NDNA3 (compound 14) is a selective inhibitor of Hsp90α (IC50: 0.51 μM). NDNA3 is a permanently charged analog with low membrane permeability and low toxicity to Ovcar-8 (IC50: 12.66 μM) and MCF-10A (IC50: 11.72 μM) cells. NDNA3 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins[1].
Target Antigen
HSP; Potassium Channel
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/ndna3.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCCOC1=CC2=C(CN(C(C3=CC=C(O)C(SC4=CC=C(C)C(C)=C4)=C3)=O)C2)C=C1
Molecular Weight
476.63
References & Citations
[1]Reynolds TS, et al. Synthesis and Validation of the First Cell-Impermeable Hsp90α-Selective Inhibitors. ACS Med Chem Lett. 2023 Aug 8;14(9):1250-1256..
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149432/NDNA3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149432/
Clinical Information
No Development Reported
Curated Selection
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