NDNA3
NDNA3 (compound 14) is a selective inhibitor of Hsp90α (IC50: 0.51 μM) . NDNA3 is a permanently charged analog with low membrane permeability and low toxicity to Ovcar-8 (IC50: 12.66 μM) and MCF-10A (IC50: 11.72 μM) cells. NDNA3 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins[1].
Product Specifications
UNSPSC
12352005
Target
HSP; Potassium Channel
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ndna3.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCCOC1=CC2=C(CN(C(C3=CC=C(O)C(SC4=CC=C(C)C(C)=C4)=C3)=O)C2)C=C1
Molecular Formula
C28H32N2O3S
Molecular Weight
476.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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