NDNA3

NDNA3 (compound 14) is a selective inhibitor of Hsp90α (IC50: 0.51 μM) . NDNA3 is a permanently charged analog with low membrane permeability and low toxicity to Ovcar-8 (IC50: 12.66 μM) and MCF-10A (IC50: 11.72 μM) cells. NDNA3 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins[1].

Product Specifications

UNSPSC

12352005

Target

HSP; Potassium Channel

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ndna3.html

Solubility

10 mM in DMSO

Smiles

CN(C)CCCOC1=CC2=C(CN(C(C3=CC=C(O)C(SC4=CC=C(C)C(C)=C4)=C3)=O)C2)C=C1

Molecular Formula

C28H32N2O3S

Molecular Weight

476.63

References & Citations

[1]Reynolds TS, et al. Synthesis and Validation of the First Cell-Impermeable Hsp90α-Selective Inhibitors. ACS Med Chem Lett. 2023 Aug 8;14 (9) :1250-1256..