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YIAD-0205

YIAD-0205 is an orally available Aβ (1 42) aggregation inhibitor. YIAD-0205 demonstrated in vivo efficacy in an AD transgenic mouse model with five familial AD mutations (5XFAD) [1].

Product Specifications

CAS Number

2446054-34-6

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/yiad-0205.html

Solubility

10 mM in DMSO

Smiles

BrC1=C(Br)C=C(N(C(C2=CC=CC=C2)=C(CC3=CC=C(Cl)C=C3)N4C5=CC=C4)C5=N6)C6=C1

Molecular Formula

C26H16Br2ClN3

Molecular Weight

565.69

References & Citations

[1]Cha M, et al. Benzo [d] imidazole-pyrrolo [1, 2-a] pyrazine Hybrids Ameliorate Amyloid Aggregates in the Brain of Alzheimer Transgenic Mice[J]. ACS Chemical Neuroscience, 2023, 14 (17) : 3025-3034...

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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