YIAD-0205
YIAD-0205 is an orally available Aβ (1 42) aggregation inhibitor. YIAD-0205 demonstrated in vivo efficacy in an AD transgenic mouse model with five familial AD mutations (5XFAD) [1].
Product Specifications
CAS Number
2446054-34-6
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/yiad-0205.html
Solubility
10 mM in DMSO
Smiles
BrC1=C(Br)C=C(N(C(C2=CC=CC=C2)=C(CC3=CC=C(Cl)C=C3)N4C5=CC=C4)C5=N6)C6=C1
Molecular Formula
C26H16Br2ClN3
Molecular Weight
565.69
References & Citations
[1]Cha M, et al. Benzo [d] imidazole-pyrrolo [1, 2-a] pyrazine Hybrids Ameliorate Amyloid Aggregates in the Brain of Alzheimer Transgenic Mice[J]. ACS Chemical Neuroscience, 2023, 14 (17) : 3025-3034...
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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