PPARδ agonist 9
PPARδ agonist 9 (compound 21) is a PPAR�� agonist (EC50: 3.6 nM) . PPARδ agonist 9 has in vivo efficacy, reducing serum levels of MCP-1 in mice and significantly inhibiting atherosclerosis progression in the LDLr-KO model (inhibition rate: 50-60%) [1].
Product Specifications
CAS Number
928023-21-6
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pparδ-agonist-9.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(CC(O)=O)=CC(OCCC2(N3CCCC3)CCN(C4=NC5=CC=C(N=C5S4)C(F)(F)F)CC2)=C1
Molecular Formula
C26H28ClF3N4O3S
Molecular Weight
569.04
References & Citations
[1]Kato T, et al. Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4- (1-Pyrrolidinyl) piperidine Structure. J Med Chem. 2023 Aug 24;66 (16) :11428-11446..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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