PI3Kα-IN-12
PI3Kα-IN-12 (compound 13) is a highly selective PI3Kα inhibitor (IC50: 1.2 nM) . PI3Kα-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 μM, respectively. PI3Kα-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model[1].
Product Specifications
CAS Number
2966861-50-5
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kα-in-12.html
Solubility
10 mM in DMSO
Smiles
S=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)SCC(N6CCN(S(=O)(C)=O)CC6)=O
Molecular Formula
C28H36F2N10O5S3
Molecular Weight
726.84
References & Citations
[1]Tang J, et al. Design and Synthesis of 1,3,5-Triazines or Pyrimidines Containing Dithiocarbamate Moiety as PI3Kα Selective Inhibitors. ACS Med Chem Lett. 2023 Aug 9;14 (9) :1266-1274..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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