SIRT5 inhibitor 7
SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP) -induced sepsis-related acute kidney injury[1].
Product Specifications
CAS Number
2951090-00-7
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sirt5-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
S=C(NCCCNC1=NC(NC2=C(Cl)C=CC=C2)=NC=C1C(N3C[C@@H](C4=CC=CC=C4)CC3)=O)NCCC(O)=O
Molecular Formula
C28H32ClN7O3S
Molecular Weight
582.12
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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