SIRT5 inhibitor 6

SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. SIRT5 Inhibitor6 has a therapeutic potential against septic AKI in vivo[1].

Product Specifications

CAS Number

[2834736-82-0]

UNSPSC

12352005

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sirt5-inhibitor-6.html

Solubility

10 mM in DMSO

Smiles

S=C(NCCCNC1=NC(NCC2=CC=CC=C2)=NC=C1C(OCC)=O)NCCC(O)=O

Molecular Formula

C21H28N6O4S

Molecular Weight

460.55

References & Citations

[1]Luohe Mou, et al, Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66 (16) :11517-11535.