BChE/HDAC6-IN-2

BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+) . BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.

Product Specifications

CAS Number

[2925457-33-4]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; HDAC; Tau Protein

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bche-hdac6-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=CC=C1CN(CC)CC)C2=CC(NC(C3=CC(C(NO)=O)=CC=C3)=O)=CC=C2

Molecular Formula

C27H30N4O4

Molecular Weight

474.55

References & Citations

[1]Wang L, Sun T, Wang Z, Liu H, Qiu W, Tang X, Guo H, Yang P, Chen Y, Sun H. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14 (17) :3226-3248.