BChE/HDAC6-IN-1
BChE/HDAC6-IN-1 is a potent and selective dual BChE/HDAC6 inhibitor with IC50 values of 4 and 8.9 nM, respectively. BChE/HDAC6-IN-1 ameliorates the cognitive impairment in an Aβ1–42-induced mouse model and has the potental for AD research[1].
Product Specifications
CAS Number
2925457-27-6
UNSPSC
12352005
Target
Cholinesterase (ChE) ; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bche-hdac6-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=CC=C1CN(CC)CC)C2=CC(NC(C3=CC(NC(CCCCCCC(NO)=O)=O)=CC=C3)=O)=CC=C2
Molecular Formula
C34H43N5O5
Molecular Weight
601.74
References & Citations
[1]Lei Wang, ET AL. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14 (17) :3226-3248.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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