Volinanserin-d4 (hydrochloride)

Volinanserin-d4 (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity[1][2].

Product Specifications

CAS Number

[1217617-73-6]

Product Name Alternative

MDL100907-d4 (hydrochloride) ; M 100907-d4 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.62

Solubility

10 mM in DMSO

Smiles

[C@H](O)(C1=C(OC)C(OC)=CC=C1)C2CCN(C(C(C3=CC=C(F)C=C3)([2H])[2H])([2H])[2H])CC2.Cl

Molecular Formula

C22H25D4ClFNO3

Molecular Weight

413.95

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Sorensen SM, et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther. 1993 Aug;266 (2) :684-91.|[3]Ardayfio PA, et al. The 5-hydroxytryptamine2A receptor antagonist R- (+) -alpha- (2,3-dimethoxyphenyl) -1-[2- (4-fluorophenyl) ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. J Pharmacol Exp Ther. 2008 Dec;327 (3) :891-7.