J-1048

J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].

Product Specifications

CAS Number

[2374772-60-6]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK)

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/j-1048.html

Solubility

10 mM in DMSO

Smiles

FC1=CC(NC(CN2C=C(C3=CC4=NSN=C4C=C3)C(C5=CC=CC(C)=N5)=N2)=S)=CC=C1

Molecular Formula

C23H17FN6S2

Molecular Weight

460.55

References & Citations

[1]Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723.