PROTAC BTK Degrader-6
PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6) [1].
Product Specifications
CAS Number
2767204-39-5
UNSPSC
12352005
Target
Btk; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/protac-btk-degrader-6.html
Solubility
10 mM in DMSO
Smiles
O=C(CN1CCN(CC2CN(C3=CC(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)=C5C=C3)C2)CC1)N(CC6)CCC6N7C8=C(C(N)=NC=N8)C(C(C=C9)=CC=C9OC%10=CC=CC=C%10)=N7
Molecular Formula
C45H47N11O6
Molecular Weight
837.92
References & Citations
[1]Huang J, et al. Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation. Eur J Med Chem. 2023 Jul 18;259:115664.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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