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TrxR1-IN-1

TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50: 8.8 μM) . TrxR1-IN-1 has anticancer activity, with IC50s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM) . TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical[1].

Product Specifications

CAS Number

3052303-04-2

UNSPSC

12352005

Target

TrxR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trxr1-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C2=CC=C(CNC(C3=C(C=CC=C3)OC(C)=O)=O)C=C2)[Se]C4=CC=CC=C41

Molecular Formula

C23H18N2O4Se

Molecular Weight

465.36

References & Citations

[1]Zhong M, et al. Synthesis, cytotoxicity, antioxidant activity and molecular modeling of new NSAIDs-EBS derivatives. Eur J Med Chem. 2023 Jul 18;259:115662.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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