TrxR1-IN-1
TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50: 8.8 μM) . TrxR1-IN-1 has anticancer activity, with IC50s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM) . TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical[1].
Product Specifications
CAS Number
3052303-04-2
UNSPSC
12352005
Target
TrxR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trxr1-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC=C(CNC(C3=C(C=CC=C3)OC(C)=O)=O)C=C2)[Se]C4=CC=CC=C41
Molecular Formula
C23H18N2O4Se
Molecular Weight
465.36
References & Citations
[1]Zhong M, et al. Synthesis, cytotoxicity, antioxidant activity and molecular modeling of new NSAIDs-EBS derivatives. Eur J Med Chem. 2023 Jul 18;259:115662.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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