PNMT-IN-1
PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a Ki value of 1.2 nM and a IC50 value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC50 value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4) is a second generation inhibitor[1].
Product Specifications
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/pnmt-in-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(Cl)C=CC2=C1CNCC2CCCCN(C[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C=NC5=C4N=CN=C5N)O3)CC[C@H](N)C(O)=O
Molecular Formula
C27H36Cl2N8O5
Molecular Weight
623.53
References & Citations
[1]Niusha Mahmoodi, et al. Cell-Effective Transition-State Analogue of Phenylethanolamine N‑Methyltransferase. Biochemistry. 2023, 62 (15), 2257-2268.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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