MMP13-IN-5

MMP13-IN-5 (compound 13m) is a potent and selective inhibitor of MMP-2/MMP-13 (IC50=3.6 μM/14.6 μM), involved in osteoarthritis (OA) [1].

Product Specifications

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mmp13-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C(N/N=C/C1=CC=C(CNC(C2=CC=C(Br)O2)=O)C=C1)CC3=CC=C(C(O)=O)C=C3

Molecular Formula

C22H18BrN3O5

Molecular Weight

484.30

References & Citations

[1]Cuffaro D, et al. Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization. Int J Mol Sci. 2023 Jul 4;24 (13) :11098.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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