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HDAC6-IN-16

HDAC6-IN-16 (compound 5c) is a histone deacetylase 6 (HDAC6) inhibitor, based on Quinazolin-4 (3H) -One. HDAC6-IN-16 exhibits anticancer effect, inhibits colony-forming. And HDAC6-IN-16 arrests cell cycle at G2 phase and induces apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac6-in-16.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C2=CC=C(C)C=C2)C(SCC3=CC=C(C(NO)=O)C=C3)=NC4=CC=CC=C41

Molecular Formula

C23H19N3O3S

Molecular Weight

417.48

References & Citations

[1]Khetmalis YM, et al. Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4 (3H) -One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity. Int J Mol Sci. 2023 Jul 3;24 (13) :11044.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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