HDAC-IN-60

HDAC-IN-60 (compound 21a) is a potent histone deacetylase (HDAC) inhibitor. HDAC-IN-60 can promote the intracellular generation of ROS, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis[1].

Product Specifications

CAS Number

[2944459-58-7]

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-60.html

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C(OC)=CC(CCC2=CC(NCC(NO)=O)=C(OC)C=C2)=C1

Molecular Formula

C20H26N2O6

Molecular Weight

390.43

References & Citations

[1]Yang Y, et, al. Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives. ChemMedChem. 2023 Jul 3;18 (13) :e202300108.