HDAC-IN-60
Product Specifications
UNSPSC Description
HDAC-IN-60 (compound 21a) is a potent histone deacetylase (HDAC) inhibitor. HDAC-IN-60 can promote the intracellular generation of ROS, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis[1].
Target Antigen
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-60.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C(OC)=CC(CCC2=CC(NCC(NO)=O)=C(OC)C=C2)=C1
Molecular Weight
390.43
References & Citations
[1]Yang Y, et, al. Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives. ChemMedChem. 2023 Jul 3;18(13):e202300108.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149370/HDAC-IN-60-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149370/
Clinical Information
No Development Reported
CAS Number
2944459-58-7
Curated Selection
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