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HDAC-IN-59

HDAC-IN-59 (compound 13a) is a potent histone deacetylase (HDAC) inhibitor. HDAC-IN-59 can promote the intracellular generation of ROS, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis[1].

Product Specifications

CAS Number

2944459-43-0

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-59.html

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C(OC)=CC(CCC2=CC(OCC(NO)=O)=C(OC)C=C2)=C1

Molecular Formula

C20H25NO7

Molecular Weight

391.42

References & Citations

[1]Yang Y, et, al. Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives. ChemMedChem. 2023 Jul 3;18 (13) :e202300108.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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