SARS-CoV-2-IN-51

SARS-CoV-2-IN-51 (S-10) is a potent lead compound of Omicron fusion inhibitor. SARS-CoV-2-IN-51 inhibits Omicron and other variants with EC50s of 0.82-5.45 μM. SARS-CoV-2-IN-51 inhibits SARS-CoV-2 virus entry, by the direct interaction with S in the prefusion state[1].

Product Specifications

CAS Number

[3049478-88-5]

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sars-cov-2-in-51.html

Solubility

10 mM in DMSO

Smiles

O=C([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H](CC5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)C)([H])CC4)C)([H])CC3)C)C)NC9=CC%10=C(C=CC=C%10)C=C9

Molecular Formula

C58H85NO15

Molecular Weight

1036.29

References & Citations

[1]Liu M, et al. Optimization, and biological evaluation of 3-O--chacotriosyl betulinic acid amide derivatives as novel small-molecule Omicron. Eur J Med Chem. 2023 Aug 5;256:115463.