SARS-CoV-2-IN-51
SARS-CoV-2-IN-51 (S-10) is a potent lead compound of Omicron fusion inhibitor. SARS-CoV-2-IN-51 inhibits Omicron and other variants with EC50s of 0.82-5.45 μM. SARS-CoV-2-IN-51 inhibits SARS-CoV-2 virus entry, by the direct interaction with S in the prefusion state[1].
Product Specifications
CAS Number
[3049478-88-5]
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-in-51.html
Solubility
10 mM in DMSO
Smiles
O=C([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H](CC5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)C)([H])CC4)C)([H])CC3)C)C)NC9=CC%10=C(C=CC=C%10)C=C9
Molecular Formula
C58H85NO15
Molecular Weight
1036.29
References & Citations
[1]Liu M, et al. Optimization, and biological evaluation of 3-O--chacotriosyl betulinic acid amide derivatives as novel small-molecule Omicron. Eur J Med Chem. 2023 Aug 5;256:115463.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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