SIKs-IN-1
Product Specifications
UNSPSC Description
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model[1].
Target Antigen
Salt-inducible Kinase (SIK)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/siks-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(F)C=CC=C1C)C2=C(NC3CCC3)N=C(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)N=C2
Molecular Weight
507.58
References & Citations
[1]Cai X, et al. Discovery of pyrimidine-5-carboxamide derivatives as novel salt-inducible kinases (SIKs) inhibitors for inflammatory bowel disease (IBD) treatment. Eur J Med Chem. 2023 Aug 5;256:115469.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149365/SIKs-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149365/
Clinical Information
No Development Reported
CAS Number
2927557-06-8
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