Tubulin inhibitor 34
Tubulin inhibitor 34 (compound b5) is a potent anticancer agent. Tubulin inhibitor 34 can inhibit tubulin polymerization and induce G2/M arrest and apoptosis. Tubulin inhibitor 34 exhibits significant antivascular and antitumor activity[1].
Product Specifications
CAS Number
3048497-78-2
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-inhibitor-34.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C(OC)=CC(CC2=NN=C3N2N=C(C4=CC=C(C)C=C4)CS3)=C1
Molecular Formula
C21H22N4O3S
Molecular Weight
410.49
References & Citations
[1]Ji T, et, al. Discovery of novel 6-p-tolyl-3- (3,4,5-trimethoxybenzyl) -7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivative as a potent tubulin inhibitor with promising in vivo antitumor activity. Eur J Med Chem. 2023 Aug 5;256:115437. |[2]Lu L, et, al. Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists. Eur J Med Chem. 2023 Aug 5;256:115424.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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