PD-1/PD-L1-IN-31
Product Specifications
UNSPSC Description
PD-1/PD-L1-IN-31 is a PD-1/PD-L1 inhibitor (IC50=2.2 nM). PD-1/PD-L1-IN-31 promotes secretion of the IFN-γ, and induces immune activity of peripheral blood mononuclear cells (PBMCs) to inhibits tumor cells[1].
Target Antigen
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-31.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=CC=C1C2=CC=CC3=C2CC[C@@H]3OC4=NC(OC)=C(CNCCO)C=C4Cl
Molecular Weight
442.91
References & Citations
[1]Cai S, et al. Design, synthesis, and evaluation of PD-1/PD-L1 small-molecule inhibitors bearing a rigid indane scaffold. Eur J Med Chem. 2023 Aug 5;256:115468.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149356/PD-1-PD-L1-IN-31-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149356/
Clinical Information
No Development Reported
CAS Number
3049472-36-5
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