PD-1/PD-L1-IN-31

PD-1/PD-L1-IN-31 is a PD-1/PD-L1 inhibitor (IC50=2.2 nM) . PD-1/PD-L1-IN-31 promotes secretion of the IFN-γ, and induces immune activity of peripheral blood mononuclear cells (PBMCs) to inhibits tumor cells[1].

Product Specifications

CAS Number

[3049472-36-5]

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-31.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=CC=C1C2=CC=CC3=C2CC[C@@H]3OC4=NC(OC)=C(CNCCO)C=C4Cl

Molecular Formula

C24H24ClFN2O3

Molecular Weight

442.91

References & Citations

[1]Cai S, et al. Design, synthesis, and evaluation of PD-1/PD-L1 small-molecule inhibitors bearing a rigid indane scaffold. Eur J Med Chem. 2023 Aug 5;256:115468.