COX-2-IN-33
COX-2-IN-33 (compound 5f) is a COX-2 inhibitor (IC50=45.5 nM), as well as a potential anti-inflammatory agent. COX-2-IN-33 inhibits in vivo pro-inflammatory cytokine production and keep gastric safety[1].
Product Specifications
CAS Number
3049405-60-6
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-33.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=[N+]([O-])ON=C1C2=CC=CC=C2)C3=NN(C4=CC=CC(C(F)(F)F)=C4)C(CCl)=N3
Molecular Formula
C20H13ClF3N5O4
Molecular Weight
479.80
References & Citations
[1]Li SM, et al. Synthesis and anti-inflammatory activity evaluation of NO-releasing furoxan/1,2,4-triazole hybrid derivatives. Eur J Med Chem. 2023 Sep 5;257:115496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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