Aurora kinase-IN-4

Aurora kinase-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM) . Aurora kinase-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora kinase-IN-4 can be used for research of triple negative breast cancer (TNBC) [1].

Product Specifications

CAS Number

[2877011-84-0]

UNSPSC

12352005

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aurora-kinases-in-4.html

Solubility

10 mM in DMSO

Smiles

CN1CCN(C2=CC(N=C(C3=CC=C(NC(C=C)=O)C=C3)N=C4NC5=NNC(C)=C5)=C4C=C2)CC1

Molecular Formula

C26H28N8O

Molecular Weight

468.55

References & Citations

[1]Zhang B, et al. Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer. Eur J Med Chem. 2023 Aug 5;256:115457.