DG1
DG1 (Compound 8Nc) is a Thymidylate Synthase (TS) inhibitor that affects cancer angiogenesis and metabolic reprogramming in NSCLC cells. DG1 can effectively inhibit the expression of CD26, ET-1, FGF-1 and EGF. DG1 also effectively inhibits the proliferation of cancer tissue in the A549 xenograft mouse model[1].
Product Specifications
UNSPSC
12352005
Target
Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dg1.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(NC=C1S(=O)(NC2=CC=CC(C(N/N=C/C3=CC(C)=CC=C3)=O)=C2)=O)=O
Molecular Formula
C19H17N5O5S
Molecular Weight
427.43
References & Citations
[1]Dong G, et al. Discovery of novel thymidylate synthase (TS) inhibitors that influence cancer angiogenesis and metabolic reprogramming in NSCLC cells. Eur J Med Chem. 2023 Oct 5;258:115600.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS701807-01 24 Well (LIMIT 1)
Human Hepatitis D virus IgM, HDV IgM ELISA Kit
Sign In for Pricing
View Details MBS701807-02 48 Well
Human Hepatitis D virus IgM, HDV IgM ELISA Kit
Sign In for Pricing
View Details MBS701807-03 96 Well
Human Hepatitis D virus IgM, HDV IgM ELISA Kit
Sign In for Pricing
View Details MBS701807-04 5x 96 Well
Human Hepatitis D virus IgM, HDV IgM ELISA Kit
Sign In for Pricing
View Details MBS701807-05 10x 96 Well
Human Hepatitis D virus IgM, HDV IgM ELISA Kit
Sign In for Pricing
View Details 
GTR15238372 1 Vial
Lentiviral mouse Ankhd1 shRNA (UAS) - Lentiviral mouse Ankhd1 shRNA (UAS, iRFP) plasmid
Sign In for Pricing
View Details