NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an NF-κB inhibitor that can improve heart failure by reducing oxidative stress and inflammation by regulating Nrf2/NF-κB signaling pathway. NF-κB-IN-10 inhibits LPS-induced NO production and expression of iNOS and COX-2 in RAW264.7 cells. NF-κB-IN-10 can be used in the research of cardiovascular diseases[1].
Product Specifications
CAS Number
3052257-09-4
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nf-κb-in-10.html
Solubility
10 mM in DMSO
Smiles
CC(N1N=C(C)CC1C2=C(OC)C=C(OC)C=C2/C=C/C3=CC=C(OCCCC)C=C3)=O
Molecular Formula
C26H32N2O4
Molecular Weight
436.54
References & Citations
[1]Yang X, et al. Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway. Eur J Med Chem. 2023 Oct 5;258:115602.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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