MtUng-IN-1

MtUng-IN-1 (Compound 18a) is a Uracil DNA glycosylase of Mycobacterium (MtUng) inhibitor (IC50: 300 μM) . MtUng-IN-1 can be used for research of cancers and infectious diseases[1].

Product Specifications

CAS Number

[359826-99-6]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/mtung-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NC(NC/1=O)=O)C1=C/C2=CC=C(OCC(OC)=O)C=C2

Molecular Formula

C14H12N2O6

Molecular Weight

304.25

References & Citations

[1]Kesharwani S, et al. Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment. Eur J Med Chem. 2023 Oct 5;258:115604.