Anticancer agent 133

Anticancer agent 133 (compound Rh2) is an anti-cancer agent with cytotoxic and antimetastatic activities. Anticancer agent 133 induces cell cycle arrest, apoptosis, and autophagy. Anticancer agent 133 also inhibits cell metastasis via suppression of EGFR expression mediated by FAK-regulated integrin β1[1].

Product Specifications

CAS Number

[2758905-51-8]

UNSPSC

12352005

Target

Apoptosis; Autophagy; EGFR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-133.html

Solubility

10 mM in DMSO

Smiles

Cl[Rh]12(Cl)([N]#CC)[N]3=C(C(N2C4=CC=CC=C4)=O)C(Cl)=CC=C3N5C(C6=CC=CC=C6)=CC(C)=[N]51

Molecular Formula

C24H19Cl3N5ORh

Molecular Weight

602.71

References & Citations

[1]Gu YQ, et al. Rhodium (III) -Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy. J Med Chem. 2023 Jul 27;66 (14) :9592-9606.